Whitney L. Hough
- Courses1
- Reviews1
- School: University of South Alabama
- Campus:
- Department: Chemistry
- Email address: Join to see
- Phone: Join to see
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Location:
307 N. University Blvd
Mobile, AL - 36688 - Dates at University of South Alabama: April 2015 - April 2015
- Office Hours: Join to see
Biography
University of South Alabama - Chemistry
Director at TreMonti Consulting
Management Consulting
Whitney
Hough
Cincinnati, Ohio Area
Specialties: Technology Transfer, Innovation, Business Development, IP Assessment, Commercialization Strategy, Project Management, and Market Research
Experience
The University of Alabama
Adjunct Professor
- Taught undergraduate level course: Management 286 titled "Entrepreneurship, Creativity, and Ideation" in Fall 2015 with 15 students
- Taught undergraduate level course: Management 386 titled "Foundations of Entrepreneurship" in Spring 2015 with 12 students and Fall 2016 with 33 studentsTreMonti Consulting
Director
- Assist universities, research facilities, hospitals, and private organizations with Technology Transfer services ranging from marketing and assessments to serving as in-house technology transfer office.
University of South Alabama
Adjunct Professor
- Developed online graduate-level course titled “Entrepreneurship in the Sciences” EXT 583
- Course blends variety of subjects from technical writing to patent law to laboratory development to provide a base for scientists and engineers to understand the development of technology.
- Teach online undergraduate-level course "Survey of Inorganic and Organic Chemistry" CH 101The University of Alabama Office for Technology Transfer
Assistant Director
- Manage approximately 150 issued and pending patents to topics such as software, materials, antennas, screening methods, and electrical devices.
- Draft material transfer agreements, non-disclosure agreements, and licensing agreements for faculty, staff, and students.
- Develop and implement commercialization action plan for each technology while working with legal counsel on protection and prosecution.
- Partner with Sales Department to market new technologies to customers with over 1000 companies contacted and 30+ teleconferences to date.
- Supervise ~11 interns in the Fall and Spring semesters along with 5 in the Summer semester.The University of Alabama Office for Technology Transfer
Venture Development Associate
- Oversee invention disclosure process from initial contact to patent protection; changes in procedure resulted in double-digit increases each year.
- Established two student internships programs to assist staff, streamline operations, and increase efficiency.
- Developed market entry strategy for Advance Research Projects Agency-Energy (ARPA-e) grant on electric vehicles; secured additional funding of over $1 million
- Mentored university technology start-ups in areas from chemistry, software, materials, and circuitry to determine product and market development strategies; $100,000+ secured in funding
- Managed prototyping process for wireless energy technology that received $23,500 in seed funding; with a prototype in 5 months and a $100,000 licensing agreement to a start-up company
Education
University of Alabama
M.S.
Chemistry
University of Alabama
Ph.D.
Chemistry
The University of Alabama
MBA
Strategy - Innovation Management
The University of Alabama
Adjunct Professor
- Taught undergraduate level course: Management 286 titled "Entrepreneurship, Creativity, and Ideation" in Fall 2015 with 15 students - Taught undergraduate level course: Management 386 titled "Foundations of Entrepreneurship" in Spring 2015 with 12 students and Fall 2016 with 33 students
Publications
The Third Evolution of Ionic Liquids: Active Pharmaceutical Ingredients
New Journal of Chemistry
A modular, ionic liquid (IL)-based strategy allows compartmentalized molecular level design of a wide range of new materials with tunable biological, as well as the well known physical and chemical, properties of ILs, which thus deserve consideration as ‘tunable’ active pharmaceutical ingredients (APIs) with novel performance enhancement and delivery options. IL strategies can take advantage of the dual nature (discrete ions) of ILs to realize enhancements which may include controlled solubility (e.g., both hydrophilic and hydrophobic ILs are possible), bioavailability or bioactivity, stability, elimination of polymorphism, new delivery options (e.g., slow release or the IL-API as ‘solvent’), or even customized pharmaceutical cocktails. Here we exemplify this approach with, among others, lidocaine docusate (LD), a hydrophobic room temperature IL which, when compared to lidocaine hydrochloride, exhibits modified solubility, increased thermal stability, and a significant enhancement in the efficacy of topical analgesia in two different models of mouse antinociception. Studies of the suppression of nerve growth factor mediated neuronal differentiation in rat pheochromocytoma (PC12) cells suggests potential differences between LD and lidocaine hydrochloride at the cellular level indicating an entirely different mechanism of action. Taken together these results suggest that the unique physiochemical properties of ILs in general, may confer a novel effect for the bioactivity of an API due to (at least) slow-release properties in addition to novel delivery mechanisms.
The Third Evolution of Ionic Liquids: Active Pharmaceutical Ingredients
New Journal of Chemistry
A modular, ionic liquid (IL)-based strategy allows compartmentalized molecular level design of a wide range of new materials with tunable biological, as well as the well known physical and chemical, properties of ILs, which thus deserve consideration as ‘tunable’ active pharmaceutical ingredients (APIs) with novel performance enhancement and delivery options. IL strategies can take advantage of the dual nature (discrete ions) of ILs to realize enhancements which may include controlled solubility (e.g., both hydrophilic and hydrophobic ILs are possible), bioavailability or bioactivity, stability, elimination of polymorphism, new delivery options (e.g., slow release or the IL-API as ‘solvent’), or even customized pharmaceutical cocktails. Here we exemplify this approach with, among others, lidocaine docusate (LD), a hydrophobic room temperature IL which, when compared to lidocaine hydrochloride, exhibits modified solubility, increased thermal stability, and a significant enhancement in the efficacy of topical analgesia in two different models of mouse antinociception. Studies of the suppression of nerve growth factor mediated neuronal differentiation in rat pheochromocytoma (PC12) cells suggests potential differences between LD and lidocaine hydrochloride at the cellular level indicating an entirely different mechanism of action. Taken together these results suggest that the unique physiochemical properties of ILs in general, may confer a novel effect for the bioactivity of an API due to (at least) slow-release properties in addition to novel delivery mechanisms.
Ionic Liquids Then and Now: From Solvents to Materials to Active Pharmaceutical Ingredients
Bulletin of the Chemical Society of Japan
Ionic liquids (ILs) have evolved from salts studied primarily for their physical properties (low melting salts which could be used as solvents) to tunable materials based upon the physical, chemical, and now even biological properties that can be introduced through either ion. In this perspective, we follow this interesting evolution with respect to our work in this growing field, and discuss possible future directions, such as the use of ILs as active pharmaceutical ingredients (APIs).
The Third Evolution of Ionic Liquids: Active Pharmaceutical Ingredients
New Journal of Chemistry
A modular, ionic liquid (IL)-based strategy allows compartmentalized molecular level design of a wide range of new materials with tunable biological, as well as the well known physical and chemical, properties of ILs, which thus deserve consideration as ‘tunable’ active pharmaceutical ingredients (APIs) with novel performance enhancement and delivery options. IL strategies can take advantage of the dual nature (discrete ions) of ILs to realize enhancements which may include controlled solubility (e.g., both hydrophilic and hydrophobic ILs are possible), bioavailability or bioactivity, stability, elimination of polymorphism, new delivery options (e.g., slow release or the IL-API as ‘solvent’), or even customized pharmaceutical cocktails. Here we exemplify this approach with, among others, lidocaine docusate (LD), a hydrophobic room temperature IL which, when compared to lidocaine hydrochloride, exhibits modified solubility, increased thermal stability, and a significant enhancement in the efficacy of topical analgesia in two different models of mouse antinociception. Studies of the suppression of nerve growth factor mediated neuronal differentiation in rat pheochromocytoma (PC12) cells suggests potential differences between LD and lidocaine hydrochloride at the cellular level indicating an entirely different mechanism of action. Taken together these results suggest that the unique physiochemical properties of ILs in general, may confer a novel effect for the bioactivity of an API due to (at least) slow-release properties in addition to novel delivery mechanisms.
Ionic Liquids Then and Now: From Solvents to Materials to Active Pharmaceutical Ingredients
Bulletin of the Chemical Society of Japan
Ionic liquids (ILs) have evolved from salts studied primarily for their physical properties (low melting salts which could be used as solvents) to tunable materials based upon the physical, chemical, and now even biological properties that can be introduced through either ion. In this perspective, we follow this interesting evolution with respect to our work in this growing field, and discuss possible future directions, such as the use of ILs as active pharmaceutical ingredients (APIs).
Ionic Liquids With Dual Biological Function: Sweet and Anti-Microbial, Hydrophobic Quaternary Ammonium-Based Salts
New Journal of Chemistry
The dual nature of ionic liquids has been exploited to synthesize materials that contain two independent biological functions by combining anti-bacterial quaternary ammonium compounds with artificial sweetener anions. The synthesis and physical properties of eight new ionic liquids, didecyldimethylammonium saccharinate ([DDA][Sac]), didecyldimethylammonium acesulfamate ([DDA][Ace]), benzalkonium saccharinate ([BA][Sac]), benzalkonium acesulfamate ([BA][Ace]), hexadecylpyridinium saccharinate ([HEX][Sac]), hexadecylpyridinium acesulfamate ([HEX][Ace]), 3-hydroxy-1-octyloxymethylpyridinium saccharinate ([1-(OctOMe)-3-OH-Py][Sac]), and 3-hydroxy-1-octyloxymethylpyridinium acesulfamate ([1-(OctOMe)-3-OH-Py][Ace]), are reported, as well as the single crystal structures for [HEX][Ace] and [1-(OctOMe)-3-OH-Py][Sac]. Determination of anti-microbial activities is described for six of the ILs. While some exhibited decreased anti-microbial activity others showed a dramatic increase. For two of the ionic liquids, [DDA][Sac] and [DDA][ACE], oral toxicity, skin irritation, and deterrent activity was also established. Unfortunately, both ILs received a Category 4 (harmful) rating for oral toxicity and skin irritation. However, deterrent activity experiments point to use as an insect deterrent, as both ILs scored either “very good” or “good” against several types of insects.
