Resume

• 2001

  Ph.D.

  Organic Chemistry

  Michigan State University

• 1994

  B.S.

  Chemistry

  Michigan State University

• •Planning and organizing the ACS OSU chapter to perform hands on chemistry demonstrations for K-12 students at three events yearly. \n•Performed chemistry demonstrations at the Women in Science Conference for 900 middle and high school girls for the past five years in a row\n•Performed chemistry demonstrations for 500 middle school students at the OSU Women’s Basketball team’s Kid Day for the past four years in a row\n•Performed chemistry demonstration for 500 preschool to 5th grade youths at the Oklahoma Science Museum on chemistry day for the past four years in a row \n

  OSU ACS Student Chapter

  Chromatography

  Spectroscopy

  Lifesciences

  Organic Synthesis

  Cancer

  HPLC

  Science

  Drug Design

  Biochemistry

  Purification

  Catalysis

  LC-MS

  Drug Discovery

  Chemistry

  NMR

  Organometallic Chemistry

  NMR spectroscopy

  Mass Spectrometry

  Medicinal Chemistry

  Organic Chemistry

  Palladium-Catalyzed Silane/Siloxane Reductions in the One-Pot Conversion of Nitro Compounds into their Amines

  Hydroxylamines

  Amides

  Sulfonamides

  and Carbamates

  Palladium-Catalyzed Silane/Siloxane Reductions in the One-Pot Conversion of Nitro Compounds into their Amines

  Hydroxylamines

  Amides

  Sulfonamides

  and Carbamates

  Nickel catalyzed deoxygenative cross-coupling of benzyl alcohols with aryl-bromides

  Pd-Catalyzed Silicon Hydride Reductions of Aromatic and Aliphatic Nitro Groups

  Room Temperature Dehalogenation of Chloroarenes by Polymethylhydrosiloxane (PMHS) Under Palladium Catalysis

  Regioselective Synthesis of Enones via a Titanium Promoted Coupling of Unsymmetrical Alkynes with Weinreb Amides

  Zinc-Catalyzed Silylation of Terminal Alkynes

  Casein Kinase 1δ Dependent Wee1 Degradation

  Palladium-Catalyzed Hydrodehalogenations by Fluoride Activated PMHS

  Titanium-Promoted Cross-Coupling for the Selective Synthesis of Polysubstituted

  Conjugated Amides

  Modular Synthesis of Tetra-Substituted Furans from Alkynes

  Weinreb Amides

  and Aldehydes

  Sterically Directed Iridium-Catalyzed Hydrosilylation of Alkenes in the Presence of Alkynes

  Casein Kinase 1δ is an APC/CCdh1 Substrate that Regulates Cerebellar Granule Cell Neurogenesis

  Ni/Ti Dual Catalytic Cross-Coupling of Nitriles and Organobromides to Access Ketones

  C-O Hydrogenolysis Catalyzed by Pd-PMHS Nanoparticles in the Company of Chloroarenes

  Development of Highly Selective Casein Kinase 1δ/1ε (CK1δ/ε) Inhibitors with Potent Antiproliferative Properties

  Ronald

  Oklahoma State University

  Broad Institute of Harvard and MIT

  Scripps Florida

  The Scripps Research Institute - Florida campus

  Jupiter

  Florida

  Working on medicinal chemistry projects targeting cancer and neurological diseases by performing SAR and optimization to improve DMPK properties

  and designing analogs to circumvent patent coverage while maintaining activity. \n \n-Designing and synthesizing dual inhibitors of TBK1/IKKi for the treatment of prostate cancer.\n\n-Analyzing high throughput screening data for inhibitors of neutral ceramidase (nCDase) for colon cancer treatment and prevention. Prioritizing hit series for compounds that are most amendable for follow-up studies. Performing initial rounds of SAR through the synthesis and purchase of analogs.\n\n-Optimizing a neuroprotective lead hit targeting protein misfolding in neurological diseases. \n\nPast Projects:\n-Prepared compounds for photoaffinity labeling of RNA targets and use in RNA binding assays.\n-Designed a benzimidazole library (solid phase and DEL) to target RNA

  Staff Scientist

  The Scripps Research Institute - Florida campus

  I developed an alkyne connected solid support to merge diversity oriented synthesis (DOS) and target identification. I also developed a zinc catalyzed silylation of terminal alkynes.

  Broad Institute of Harvard and MIT

  Postdoctoral Researcher

  While in the Roush group I worked on two medicinal chemistry projects. The goal of the first project was to probe the substrate binding pockets of the protein arginine methyltransferase (PRMT) isoforms for scaffolds that could lead to isoform-selective inhibitors. This was accomplished by attaching a diverse array of small molecules to a modified adenosine handle to probe the arginine binding pocket of the PRMTs. This strategy has afforded four new PRMT inhibitors that show selectivity for PRMT1 and/or PRMT5.\n\nIn the second medicinal chemistry project I performed SAR and lead optimization on a purine scaffold to increase potency and selectivity as an inhibitor of Wee1 degradation and mitotic entry. The initial lead hit was optimized from an IC50 of 650nM to an analog with an IC50 of 2nM. The analogs were determined to be selective inhibitors of the kinase CK1-delta

  which resultantly inhibits Wee1 degradation

  mitotic entry

  and cerebellar granule cell proliferation. To help guide the progression of preparing new inhibitors

  all analogs were subjected to an MTT assay against the human melanoma A375 cell line. Those compounds that exhibited significant anti-proliferative activity in this assay (EC50<200 nM) were taken forward to a core set of in vitro DMPK assays to assess their drug like characteristics. Through this process we developed a series of potent and highly selective CK1δ inhibitors with potent antiproliferative activity. This has led to analogs that have in vitro and in vivo PK properties suitable for use in xenograft studies of human cancers.

  Scripps Florida

  Oklahoma State University

  Stillwater

  OK

  Research conducted in my group was in the area of organic synthesis

  specifically focusing on organometallic methodology development directed towards drug discovery applications. The primary goal was the development of reagents

  catalysts

  and methodology from earth abundant metals to prepare complex molecules in a modular and economical (atom

  redox

  step) manner with diversity. The focus of which was to apply our technology to the preparation of small molecule libraries containing natural product features

  and to the preparation of natural product-mimic libraries. The objective of which was the discovery on new pharmacological tools and lead-hits to address unmet medical needs in cancer

  infectious

  and neurological diseases. Research endeavors towards this goal focused on:\n\n•\titerative reactions of group IV metallacycles\n•\tnickel catalyzed cross-coupling of titanacycles\n•\tdual catalytic radical cross-couplings\n•\tnickel catalyzed cross-electrophile couplings of alcohols\n•\tdevelopment of new strategies for preparing and employing temporary tethers

  Assistant Professor of Chemistry

  us

  WO 2013130461 A1 20130906