Michael O'Sullivan
- Courses2
- Reviews3
- School: Art Institute of Washington
- Campus:
- Department: Fine Arts
- Email address: Join to see
- Phone: Join to see
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Location:
1820 Fort Myer Dr
Arlington, VA - 22209 - Dates at Art Institute of Washington: April 2009 - August 2010
- Office Hours: Join to see
Biography
Art Institute of Washington - Fine Arts
Postdoctoral Fellow with expertise in culture of human epithelium at the air-liquid interface. Currently exploring mechanisms of viral entry of SARS-CoV-2 and consequences of rhinovirus infection.
Michael
O'Sullivan
A postdoctoral research fellow with an extensive background in airway biology, I specialize in airway epithelial viral infections and the interactions of the epithelium with other lung tissues. I have been interested in asthma pathogenesis for the past decade and more recently have been working in the space of rhinovirus infections and how they remodel the airway. I have experience exposing well-differentiated epithelium to a variety of insults including ozone, e-cigarette toxins, compressive stress and, most recently, SARS-CoV-2 infection. Driven by a passion for research and keen interests in a wide variety of topics, I enjoy the challenges associated with driving projects to completion. A well-rounded individual with stellar team-working abilities, I strive to optimize output via the synergistic productivity associated with group work.
I completed my undergraduate and PhD studies at McGill University in the department of Physiology. In graduate school I initiated an international collaboration at Harvard, where I became a postdoctoral fellow in 2016. For the past four years I have continued my collaborative work with a wide variety of institutes, exploring lung diseases through cell-to-cell interactions. I have become an experiment in air-liquid interface culture of well differentiated human airway epithelial cells and have become intimately familiar with the ins and outs of manipulating these primary cells through use of both genetic and molecular tools.
Outside of work, I am an outdoor enthusiast. An avid hiker, camper and skier, I love spending time in the outdoors. In the city I enjoy playing hockey, golf and road cycling with friends.
Experience
Education
McGill University
PhD Candidate
Physiology
• Research intensive, thesis based program, supervised by Dr. James G. Martin, M.D., D.Sc. • Topics in respiratory physiology, airway inflammation and disease • 4.0/4.0 G.P.A. • Focus on data interpretation and presentation • Publications to date: 1 first author, 3 co-author • Independently carry out long-term research projects • Collaboration with other students, post-doctoral fellows and professors • Attend and present at international research conferences • Fast-track, accelerated program • Peer review of research articles • Membership in American Thoracic Society, Canadian Lung Association • V.P. Finance, Graduate Association of Physiology Students (2010-present)McGill University
Bachelor of Science (B.Sc.)
Physiology
• Course-based program • Exposure to a wide variety of topics regarding mammalian physiology • Elective coursework completed in economics and language studies
Publications
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
Nature Communications
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
Nature Communications
Irradiation Induces Epithelial Cell Unjamming
Frontiers in Cell and Developmental Biology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
Nature Communications
Irradiation Induces Epithelial Cell Unjamming
Frontiers in Cell and Developmental Biology
Bronchoconstriction: a potential missing link in airway remodelling
The Royal Society - Open Biology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
Nature Communications
Irradiation Induces Epithelial Cell Unjamming
Frontiers in Cell and Developmental Biology
Bronchoconstriction: a potential missing link in airway remodelling
The Royal Society - Open Biology
Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell–Airway Smooth Muscle Cell Communication through Membrane Conduits
Journal of Immunology
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
Nature Communications
Irradiation Induces Epithelial Cell Unjamming
Frontiers in Cell and Developmental Biology
Bronchoconstriction: a potential missing link in airway remodelling
The Royal Society - Open Biology
Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell–Airway Smooth Muscle Cell Communication through Membrane Conduits
Journal of Immunology
The Aftermath of Bronchoconstriction
The American Society of Mechanical Engineers
Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice
Free Radical Biology and Medicine
Sphingosine 1-Phosphate (S1P) induced Interleukin-8 (IL-8) release is mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS- 2B cells
PLoS ONE
Neutrophils Mediate Airway Hyperresponsiveness Following Chlorine-Induced Airway Injury in the Mouse
American Journal of Respiratory Cell and Molecular Biology
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse
British Journal of Pharmacology
Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4- TRIF pathway
Journal of Immunology
Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype
American Journal of Respiratory Cell and Molecular Biology
Serotonin augments smooth muscle differentiation of bone marrow stromal cells
Stem Cell Research
Airway epithelial compression promotes airway smooth muscle proliferation and contraction
American Journal of Physiology-Lung Cellular and Molecular Physiology
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes
Scientific Reports
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin
American Journal of Respiratory Cell and Molecular Biology
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
Nature Communications
Irradiation Induces Epithelial Cell Unjamming
Frontiers in Cell and Developmental Biology
Bronchoconstriction: a potential missing link in airway remodelling
The Royal Society - Open Biology
Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell–Airway Smooth Muscle Cell Communication through Membrane Conduits
Journal of Immunology
The Aftermath of Bronchoconstriction
The American Society of Mechanical Engineers
Mechanical forces induce an asthma gene signature in healthy airway epithelial cells
Scientific Reports
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