Resume

• 1975

  MPhil

  Mathematical Statistics

  Graduate Student (Evening); Mathematcal Statistics

  The George Washington University

• 1974

  Non-degree

  Statistics

  American University

• 1973

  MS

  Graduate Student: Applied Statistics

  Applied Statistics

  Carnegie Mellon University

  Non-degree

  Mathematics and Statistics

  University of Pittsburgh

• 1972

  Carnegie Mellon University

  Howard County Public Schools

  Pittsburgh

  PA

  Taught sections of Calculus III

  Linear Algebra and Statistical Methods

  Graduate Teaching Assistant in Mathematics and Statistics

  Carnegie Mellon University

• 1970

  Non-degree

  Mathematics

  State University of New York at Buffalo

• 1969

  Non-degree

  Mathematics

  State University of New York at Albany

• 1968

  Non-degree

  Mathematics

  State University of New York at Binghamton

• 1967

  University of Missouri

  State University of New York

  College at Oneonta

  Washington

  DC

  Provide statistical support to all components of the Center for Food Safety and Applied Nutrition (CFSAN). Examples include in-house laboratory studies

  food and color additive petitions review

  infant formula submission review

  adverse event reporting

  nutritional labeling

  and more. \nI was promoted to Supervisory Mathematical Statistician in the same office effective 23 December 1985

  Mathematical Statistician

  U.S. Food and Drug Administration; Center for Food Safety and Applied Nutrition

  Oneonta

  NY

  Taught in the Mathematics Department: Intro (101) course

  Calculus

  Logic

  Algebra

  Analysis

  Geometry

  Foundations

  Assistant Professor - Mathematics

  State University of New York

  College at Oneonta

  Columbia

  Missouri

  Taught four sections: Math of Finance; Plane Analytic Geometry; Calculus I and Analytic Geometry and Calculus I

  Assistant Instructor of Mathematics

  University of Missouri

  Ellicott City

  MD

  Assisted teacher and students with instruction in AP Statistics at Homewood School (Bridges program) for the period up to the AP Examination in May 2015 on the days when I was not teaching at Howard Community College..

  Temporary Consultant - Statistics Education (Part-time)

  Howard County Public Schools

  Fort Meade

  Maryland

  Computer program optimization; Research in several mathematical problems; Teaching in house mathematics and statistics course; Software development for engineering applications; Contract management; Software configuration management and other duties. Held a Top Secret security clearance. Held an Agency Professionalization Certificate as an Applied Mathematician. Department of Defense regulations prohibit me from being more specific.

  Applied Mathematician

  National Security Agency

  Columbia

  Maryland

  Teach two sections of Statistics (Math138) per semester and one during the Summer Terms as needed. The textbook used is \"Intro Stats\" 4th edition by DeVeaux

  Velleman and Boch. \nI teach mostly on the Main Campus

  and occasionally at the Laurel College Center. At LCC

  the class consists of students from both HCC and Prince Georges Community College. \nI also tutor 1 to 2 hours a week in the walk-in Math Center at all levels from Developmental Mathematics through Differential Equations

  and I serve as a substitute instructor for Math 138 or Math 122 (Ideas in Mathematics) as requested. \nI became an adjunct instructor in June 2008; was advanced to Senior Adjunct Instructor in July 2009 and Master Adjunct in January 2011. \nI became certified to teach online and hybrid at HCC in July 2014

  The course delivery system being used at HCC is Canvas with a link to the Pearson textbook site..

  Part-time: Master Adjunct Instructor of Statistics

  Mathematics Division

  Howard Community College

  Washington DC until 12/01

  then College Park

  MD

  Leader

  Statistical Applications Team. \nProvided statistical support to all components of the Center for Food Safety and Applied Nutrition (CFSAN). Examples include in-house laboratory studies

  food and color additive petitions review

  infant formula submission review

  adverse event reporting

  nutritional labeling

  and more. \nServed as member and statistician

  CFSAN Institutional Animal Care and Use Committee.\nServed on Equal Employment Opportunity and Diversity Committee \nServed as CFSAN representative to the FDA Statistical Association\nTaught one online and one hybrid Statistical Techniques course to CFSAN research and regulatory professional personnel.\nNot part of the job

  but I also provided entertainment (guitar and voice) at CFSAN and FDA ceremonial functions (award ceremonies

  FDA Centennial). This also increased visibility throughout the FDA

  and I used my entertainment ability to prompt personnel to seek our office out for statistical services.\nRetired from this position on December 31

  2011 and am a member of the FDA Alumni Association.

  Supervisory Mathematical Statistician (Biomedical)

  U.S. Food and Drug Administration; Center for Food Safety and Applied Nutrition

  American Statistical Association

  FDA Alumni Association

  American Mathematical Association of Two-Year Colleges

  National Council of Teachers of Mathematics

  Russian

  English

  CFSAN Community Service / Citizenship Award

  For professional support to the Howard County Public School System in the development of the Advanced Placement Statistics (high school) curriculum.

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  Exceptional Customer Service Award

  For the development and implementation of an online training course in Statistical Techniques for Data Analysis with CFSAN applications for CFSAN regulatory and research personnel

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  Group Recognition Award

  For dedication to the CFSAN Animal Research program including accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  CFSAN Teaam Recognition Award

  As a member of the Human Issues Task Force

  for superior performance in addressing issues that affected employees day-to-day work life related to the move (from Washington DC) to College Park.

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  CFSAN Team Recognition Award

  For successfully conducting the first CFSAN electronic submission training classes and presenting a Webcast for FDA staff and the food industry.

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  Group Recognition Award

  For development and implementation of innovative training courses at three levels in statistics to educate CFSAN professionals in the use of statistical methodology.

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  Outstanding Adjunct Instructor Award

  For outstanding teaching and development of course materials for the Statistics course Math 138.

  Howard Community College

  Distinguished Career Service Award

  For more than 32 years of exceptional service to the Center.

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  Exceptional Achievement Award

  For outstanding contributions in preparing standard operating procedures to review petitions and notifications requesting exemption from labeling requirements of the Food Allergen Labeling and Consumer Protection Act

  Food and Drug Administration

  Center for Food Safety and Applied Nutrition

  Distinguished Service Award

  For service as Consulting Statistician and member of the CFSAN IACUC from March 1987 until December 2011

  FDA / CFSAN Institutional Care and Use Committee

• 1966

  MA

  Mathematics

  Newman Club; Roman Catholic Music Ministry

  University of Missouri-Columbia

• 1962

  BS

  Mathematics

  Newman Club; Glee Club; Roman Catholic Music Ministry

  Rensselaer Polytechnic Institute

  Getting to Know Your Classroom

  Distribution Theory I

  II

  Advanced Statistical Theory I (Hypothesis Testing)

  Bayesian Inference I

  II

  Advanced Statistical Theory II (Estimation)

  Helping Students Change

  Complex Analysis I

  Canvas Faculty Training

  Advanced Probability Theory II

  Algebraic Topology I

  II

  FERPA

  General Topology I

  II

  Advanced Probability Theory I

  Foundations of Geometry

  Excel Level 2 in a Day

  Differential Geometry

  Brightlink & Camtasia

  Abstract Algebra I

  II

  Advanced ANOVA and Experimental Design

  Complex Variables

• 1959

  New York State Regents HS Diploma

  College Preparatory Program

  Mens' Chorus; Yearbook; School Newspaper

  provided guitar & vocal entertainment at dances

  Cohoes High School

• 1953

  (through 9th grade)

  College Preparatory program

  Science Club

  Civics Club

  Altar Server at St. Bernard's Church

  Keveny Memorial Academy

• Attend bimonthly meetings and offer advice as a professional statistician. Give input to current HCPSS Mathematics program

  especially Statistics education. Judge County-wide High School STEM Science Fair every February. Participate in May scrimmage to prepare the Howard and Baltimore County math teams for the June ARML tournament at Penn State.

  Howard County Public Schools

  Parent Volunteer

  Volunteered in several capacities while my children attended Trinity.\nAssisted with music at Roman Catholic Masses for children on holydays and families on other occasions.\nServed on the parent-teacher Curriculum Committee.\nGave class presentations on music

  science

  mathematics history and computers.\nChaperoned on Field Days and class trips.

  Trinity School

  Ellicott City

  MD

  Music Minister

  Assist with music at 4:30 Saturday Mass and on other occasions as needed.\nServed as a member

  music representative and consulting statistician to the parish Liturgy Committee (1979-1994)

  St. John the Evangelist Roman Catholic Church

  Columbia MD

  Public Speaking

  Research

  Adult Education

  Data Analysis

  Educational Technology

  Higher Education

  Analysis

  Curriculum Development

  Community Outreach

  PowerPoint

  Guitar & Voice - Folk

  Statistics

  Tutoring

  Microsoft Excel

  Microsoft Word

  Statistical Consulting

  Curriculum Design

  Mathematics

  Community College Teaching - Mathematics

  Statistics

  Teaching

  Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture

  Robert Sprando

  Margaret Amankwa-Sakyi (2nd)

  Saura C. Sahu (1st author)

  Usnic acid

  a natural botanical product

  is a constituent of some dietary supplements used for weight loss. It has been associated with clinical hepatotoxicity leading to liver failure in humans. The present study was undertaken for metabolism and toxicity evaluations of usnic acid in human hepatoblastoma HepG2 cells in culture. The cells were treated with the vehicle control and usnic acid at concentrations of 0–100mM for 24 h at 37 ?C in 5% CO2. Following the treatment period

  the cells were evaluated by biochemical and toxicogenomic endpoints of toxicity that included cytochrome P450 activity

  cytotoxicity

  oxidative stress

  mitochondrial dysfunction and changes in pathway focused gene expression profiles.\n\nMy role was as consulting statistician

  including input to the design of the experiment and statistical analysis of the data. The data were analyzed using a one-way analysis of variance (ANOVA). If the ANOVA was significant (P ≤ 0.050) then a least significant difference test (one-tail) was used to compare the control with each of the usnic acid concentrations. If the variances for the data were not homogeneous

  a log transformation was performed. A regression analysis was also performed on the data. If the regression line was not linear

  a curvilinear analysis was then performed.

  Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture

  Stuart Chirtel

  Dennis Hinton

  James Rorie (4th)

  Thomas FX Collins(3rd)

  James Pesta (2nd)

  Robert Sprando (1st author)

  The Effect of Vomitoxin (Deoxynivalenol) on Testicular Morphology

  Testicular Spermatid Counts and Epididymal Sperm Counts in IL-6K0 and WT Mice

  Michael J. Myers

  Dennis Gaines (4th)

  Richard B. Raybourne (3rd)

  Uma S. Babu (2nd)

  Paddy L. Wiesenfeld (1st author)

  Effect of Dietary Fish-Meal on Chicken Serum

  Liver and Spleen Fatty Acid Metabolism

  R Jones

  T Boyle

  A. Perllone (3rd)

  Joyce Njoroge (2nd)

  Maryanne Principato (1st author)

  This study was undertaken to assess the effects of orange juice and popular carbonated soft drink upon the fidelity of antibody-based antigen-capture assays and to develop simple approaches that could rescue assay performance without the introduction of additional or extensive extraction procedures. We examined the effects of orange juice and a variety of popular carbonated soft drink beverages upon a quantitative Interleukin-2 (IL-2) enzyme-linked immunosorbent assay (ELISA) assay system and a lateral flow device (LFD) adapted for the detection of staphylococcal enterotoxin B (SEB) in foods. Alterations in the performance and sensitivity of the assay were directly attributable to the food matrix

  and alterations in pH were especially critical.\n\nMy role was in the statistical analysis of the data. Differences between the beverages were evaluated by Student’s t-test and were considered to be significant at P < 0.05.

  Detection of Target Staphlyococcal Enterotoxin B Antigen in Orange Juice and Popular Carbonated Beverages with Antibody-Dependent Antigen Capture Assays

  Nicholas Olejnik

  Thomas Black

  Thomas Flynn

  Robert Sprando (4th)

  Thomas Collins (3rd)

  Uma Babu (2nd)

  Paddy Wiesenfeld (1st author)

  Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring

  Richard Newell (6th)

  Philip Sapienza (5th)

  Ivan Ross (4th)

  Chung Kim (3rd)

  Paddy Wiesenfeld (2nd)

  Saura Sahu (1st author)

  Click on the title of the paper to see a description of the research as given in the Abstract. \n\nMy role was as consulting statistician

  including input to the design of the experiment and statistical analysis of the data. The Shapiro-Wilk test showed that the data were normally distributed. Levene’s tests indicated the variances were homogenous. Therefore

  the data were analyzed with a one-way analysis of variance (ANOVA) followed by a ‘protected LSD’. This test was protected in two senses. First

  it was done only if the ANOVA yielded a value of p < 0.05. Secondly

  the ANOVA mean square error was used. A value of p<0.05 indicated statistical significance

  Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9.

  Paddy Wiesenfeld

  Saura Sahu (1st author)

  The present study was undertaken to assess

  in vitro

  the hepatotoxic potential of the food-borne mycotoxin

  deoxynivalenol (DON)

  using rat (Clone9 and MH1C1)

  mouse (NBL CL2) and human (WRL68 and HepG2) liver cells in culture. The cells were treated with DON for 24 h at 37 °C in 5% CO2 at concentrations of 0–25 mgml-1. Following the treatment period

  the cells were assayed for biochemical markers of hepatotoxicity that included three independent cytotoxicity assays

  oxidative stress and mitochondrial dysfunction. Concentration-dependent cytotoxicity of DON was observed in each of the five different liver cells derived from three different species (rat

  mouse and human) over the entire concentration range studied

  beginning at 0.1 mg ml-1.\n\nMy role was as consulting statistician

  including input to the design of the experiment and statistical analysis of the data. The data were analyzed using a one-way analysis of variance (ANOVA). If the ANOVA was significant (p < 0.050)

  then a least significant difference (LSD) test (one-tail) was used to compare the control with each of the DON dose levels. If the variances for the data were not homogeneous a log transformation was performed. A regression analysis was also performed on the data. If the regression line was not linear

  a curvilinear analysis was then performed.

  Comparative Hepatotoxicity of Deoxynivalenol in Rat

  Mouse and Human Liver Cells in Culture

  Mark Bryant (4th)

  Jan Johannessen (3rd)

  S Bhathena (2nd)

  Kathleen Elwood (1st author)

  Because sugar alcohols can be used as bulk sweeteners and because of their possible lower energy values

  interest in them has increased. Sorbitol and xylitol

  two sugar alcohols

  are hydrogenated monosaccharides that have widespread application. Male Fisher 344 rats were fed semipurified diets containing glucose without or with either 1 00/o or 20% sorbitol or xylitol for 8 weeks following a 4-week adaptation period.\n\nMy role was as consulting statistician

  including input to the design of the experiment and statistical analysis of the data. A one-way analysis of variance (ANOVA) using the general linear models (GLM) procedure was used to test for main effects where more than two groups were being compared. If the p value of the ANOVA was less than 0.10

  pairwise comparisons were done using at-test. If only two groups were being compared

  at-test was used. For food efficiency

  the ANOVA and t-test above were replaced by the nonparametric Kruskal-Wallis one-way ANOVA and the two-sample Kruskal-Wallis test. Differences with p values less than 0.05 were considered to be statistically significant.\n

  Biomarkers used to assess the effect of dietary xylitol or sorbitol in the rat

  Dennis Ruggles (3rd)

  Paddy Wiesenfeld (2nd)

  Saura Sahu (1st author)

  Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures

  Uma Babu (2nd)

  Paddy Wiesenfeld (1st author)

  Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells

  Robert Sprando

  Thomas Collins

  Chung Kim (6th)

  Saura Sahu (5th)

  Ivan Ross (4th)

  Paddy Wiesenfeld (3rd)

  Philip Sapienza (2nd)

  Thomas Flynn (1st author)

  Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats

  Robert Sprando

  Thomas Collins

  Saura Sahu (7th)

  Chung Kim (6th)

  Ivan Ross (5th)

  Cheryl Ford (4th)

  Thomas Flynn (3rd)

  Philip Sapienza (2nd)

  Paddy Wiesenfeld (1st author)

  Effects of Oral Androstenedione on Phospholipid Fatty Acids

  ATP

  Caspase-3

  Prostaglandin E2 and C-Reactive Protein in Serum and Livers of Pregnant and Non-pregnant Female Rats

  Curtis Barton (5th)

  Dennis Hinton (4th)

  Rene Sotomayor (3rd)

  M.C. Chou (2nd)

  Saura Sahu (1st author)

  Effect of Intermittent Exposure of Aflatoxin B1 on Hepatic and Testicular Glutathione S-transferase in rats

  Chung Kim

  Dennis Ruggles

  Robert Sprando (4th)

  Widmark Johnson (3rd)

  Thomas Boyle (2nd)

  Ivan Ross (1st author)

  Free fatty acids (FFAs) are known to be markers of cellular membrane degradation through lipid peroxidation and are substrates for the production of reactive oxygen species (ROS). Oxidative stress

  due to overproduction of ROS

  may facilitate cellular insult by various toxicants. The ability of the rat conceptus to respond to toxic stress may be critical for normal development. In this study

  the effects of the environmental toxicant sodium arsenite (NaAsO2) on FFAs were investigated after administering a single oral dose

  in water and in a lipid medium

  to pregnant rats on gestational day (GD) 10

  a time point at mid-organogenesis. NaAsO2 was administered in deionized water (AsH2O) or in half and half dairy cream (AsHH) at a dose of 41 mg NaAsO2/kg body weight. Control animals were treated with either dairy cream (HH) or deionized water. \n\nMy role was as consulting statistician

  including input to the design of the experiment and statistical analysis of the data. The Shapiro-Wilk Test was performed for each combination of FFAs

  groups and organs to determine whether the data followed a normal distribution. If this test yielded a p value < 0.05

  it was concluded that the data were not normal. In order to decide whether to perform a parametric analysis (which assumes normality) or a non-parametric analysis

  the majority of the outcomes for the groups were compared. All FFAs in the liver and fetal brain were non-normal. In the maternal brain

  plasma and kidney

  myristic

  palmitoleic

  oleic

  linoleic

  arachidonic and docosahexaenoic acids were considered non-normal. Also

  in the maternal brain

  plasma and kidney

  myristoleic

  palmitic

  oleic

  linoleic and stearic acids were normal. Subsequent statistical analysis was performed accordingly. Pairwise comparisons were performed to compare between groups

  AsH2O and AsHH

  AsH2O and H2O

  AsHH and HH and HH and H2O. The non-parametric test was the Mann-Whitney U test. The parametric test was the Student’s t test.

  Free Fatty Acids Profile of the Fetal Brain and the Plasma

  Liver

  Brain and Kidneys of Pregnant Rats Treated with Sodium Arsenate at Mid-Organogenesis

  Joyce Nkoroge (4th)

  R.L. Jones (3rd)

  Thomas Boyle (2nd)

  Maryanne Principato (1st author)

  Click on the title of the paper to see a description of the research as given in the Abstract. \n\nMy role was as consulting statistician

  including input to the design of the experiment and statistical analysis of the data. A Shapiro-Wilk test was done to test each data set separately by week (type I

  SEB boiled; type II

  treated with SEB) for normality. Data obtained for pH and concentrations of lactic acid and acetaldehyde were normal. However

  SEB concentration determinations were not. For the normal data

  a three-way analysis of variance (ANOVA) was performed to test for interactions among the response parameters. For each level of the SEB-treated and SEBboiled variables

  we performed a one-way ANOVA on ‘‘week’’ with the Welch procedure when the variances were not equal as determined by Levene’s test. When the ANOVA was significant (p<0.05)

  a pairwise comparison of all weeks using a protected LSD t test was performed. For each week and for type I (boiled) and type II (nonboiled) data sets separately

  an F test for equality of variances was performed

  followed by a t test to check differences between SEB-treated and control groups. When the variances were unequal

  a Satterwaithe correction to the degrees of freedom was applied in the t test. We performed these analyses for each week and for SEB-treated and control groups separately to check for differences between boiled and nonboiled samples. Since the SEB concentrations were not normal the nonparametric counterparts of the above procedures were used. A Friedman ANOVA was used to test for the presence of an interaction. For each level of the SEBboiled variable

  a Kruskal-Wallis test was done to check for an overall week difference. If the difference was determined to be significant

  paired week comparisons were done using the Mann-Whitney test. For each week

  a M-W test was performed to check differences between the SEB-spiked and control groups

  Effect of Thermal Processing during Yogurt Production Upon the Detection of Staphylococcal Enterotoxin B

  Statistical applications to food safety. Consultation on in-house laboratory studies. Review of industry-submitted food additive petitions.\nTeaching.\n\nSpecialties: Statistical analysis

  especially with Biological applications\nTeaching at the college and professional level\nGuitar and music (Religious Music (RC) and folk - US Historical

  Irish/Celtic

  UK

  Australia)

  Michael

  O'Donnell

  U.S. Food and Drug Administration; Center for Food Safety and Applied Nutrition

  National Security Agency

  Mathematics Division

  Howard Community College