Resume

• 20120149631

  US 8

  636 B2

• 20100004187

  American Society of Microbiology

  American Association for the Advancement of Science

  Sponsors of the March for Science!

  French

  Dutch

  STEM Research Exemplar

  The Research Exemplar Project seeks to honor and learn from individuals doing high-quality

  high-impact

  federally-funded research who also maintain an impressive reputation for professionalism and integrity in their work.

  The Research Exemplar Project Washington University School of Medicine in St. Louis

• 1990

  PhD

  Microbiology

  University of Virginia

• 1986

  BSc

  Biochemistry

  University of Victoria

• 404

  US 8

  636 B2

• Healed by a Crocodile: the Search for New Antibiotics: Monique van Hoek at TEDxGeorgeMasonU

  Talk given at TEDxGeorgeMasonU

  April 6th 2013. Read full bios and event information at www.TEDxGeorgeMasonU.com Dr. Monique van Hoek is a scientist in search of interesting and useful problems. Using her training in biochemistry (UVIC

  BSc

  1990) and microbiology (UVA

  PhD

  1997)

  combined with her experience in industry

  she is currently seeking new approaches to antibiotics in the face of the impending crisis of antibiotic resistance.

  Healed by a Crocodile: the Search for New Antibiotics: Monique van Hoek at TEDxGeorgeMasonU

  Antimicrobial Peptides

  Francisella

  PCR

  Scientific Project Management

  Aerosol biology

  Science

  Ligand Gated Ion Channels

  Biofilms

  Cell Culture

  Antibiotics

  Grant Writing

  Protein Biochemistry

  Infectious Diseases

  Slack.com

  Scientific Writing

  Bioinformatics

  Biochemistry

  Chronic Wound Infection

  Antimicrobial Resistance

  Gram-negative bacteria

  Azithromycin effectiveness against intracellular infections of Francisella.

  Barbara J Mann

  Aping Qin

  Lyman Hunter

  Saira Ahmad Chaudry

  Azithromycin effectiveness against intracellular infections of Francisella.

  SuHua Han

  Antimicrobial activity of human beta-defensins and induction by Francisella.

  Cindy S Dowd

  Robin D Couch

  G San Jose

  Emily Uh

  H Kahn

  M Sargent

  Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy.

  WeiDong Zhou

  Demetrios Matrakas

  Tony Pierson

  Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine.

  Frank A. deLatour

  Antimicrobial activity of the Naja atra cathelicidin and related small peptides.

  Scott N. Dean

  Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37.

  Scott N. Dean

  Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus.

  Anne B. Verhoeven

  Wiliam T. Boswell

  Tony Pierson

  Francisella philomiragia biofilm formation and interaction with the aquatic protist Acanthamoeba castellanii.

  Charles Bailey

  Dzung C Thach

  Eddie Chang

  Saira Chaudhry

  Anne verhoeven

  Temporal transcriptional response during infection of Type II alveolar epithelial cells with Francisella tularensis LVS supports a general host suppression and bacterial uptake by macropinocytosis.

  S.J. Parsons

  Tyrosine phosphorylation and regulated secretion in chromaffin cells : A postulated role for c-Src family tyrosine kinases and phosphotyrosine phosphatases in bovine adrenal medullary chromaffin cell secretion

  Antimicrobial and antibiofilm activity of cathelicidins and short

  synthetic peptides against Francisella

  Myung-Chul Chung

  Scott N Dean

  Appl Environ Microbiol.

  Burkholderia Diffusible Signal Factor Signals to Francisella novicida To Disperse Biofilm and Increase Siderophore Production.

  Ryan S. Mackie

  Resistance of Francisella novicida to fosmidomycin associated with mutations in the glycerol-3-phosphate transporter

  S. J. Parsons

  J. M. Lindstrom

  Michael E. Cox

  J. T. Hackett

  K. Wang

  Regulation of the neuronal nicotinic acetylcholine receptor by SRC family tyrosine kinases.

  Ryan Blower

  Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis

  Jawaid

  S.

  H. Seidle

  W. Zhou

  H. Abdirahman

  M. Abadeer

  J. H. Hix

  M. L. van Hoek

  and R. D. Couch.

  Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

  Ryan S Mackie

  Resistance of Francisella novicida to fosmidomycin associated with mutations in the glycerol-3-phosphate transporter.

  Anne B. Verhoeven

  Francisella novicida forms in vitro biofilms mediated by an orphan response regulator.

  Carlos Rodriguez

  Large Scale Discovery and De Novo-Assisted Sequencing of Cationic Antimicrobial Peptides (CAMPs) by Microparticle Capture and Electron-Transfer Dissociation (ETD) Mass Spectrometry

  Moushimi Amaya

  Protein prenylation: A new mode of host-pathogen interaction.

  Monique

  van Hoek

  George Mason University

  Roche

  Studying Francisella

  especially its microbial ecology and biofilm formation (Durham-Colleran et al

  Microb Ecol. 2010). Interaction of Francisella with aquatic amoeba (Verhoeven et al

  Biological Bulletin

  2010) Discovering novel vaccine candidates

  such as Francisella outer membrane vesicles (Pierson et al

  Journal Proteome Research

  2011). Examining host response to Francisella infection (Bradburne et al

  JBC

  2013) by measuring the transcriptome in lung (alveolar) epithelial cells. Identification of macropinocytosis as a mechanism of Francisella entry into lung (alveolar) epithelial cells (Bradburne et al

  JBC

  2013).

  George Mason University

  George Mason University

  Manassas

  VA

  Study of bacterial physiology

  especially for Gram-negative bacteria and Francisella in particular. Study of antimicrobial compounds

  such as antimicrobial peptides. Discovery of novel antimicrobial peptides from extreme animals. Study of anti-biofilm compounds and understanding biofilm mechanisms

  including small-molecules involved in cell-cell communication in bacteria. Identification of Francisella response to BDSF

  a small molecule produced by Burkholderia cepacia complex (Dean et al

  AEM

  2105). Cathelicidins (Antimicrobial Peptide LL-37) as a potential treatment for polymicrobial infected wounds (Duplantier et al

  Front Immunol. 2013)

  Associate Professor

  Fairfax

  VA

  Research focus on bio-threat pathogens

  gram-negative bacteria

  novel anti-bacterials

  and novel anti-biofilm agents.

  Professor

  George Mason University

  Developed and launched biochemical and cell transfection reagents

  provided support for in vitro transcription-translation platform.

  Roche

  Research Assistant Professor

  Graduate Coordinator Biodefense Graduate Program

  George Mason University