Resume

• 2004

  Doctor of Philosophy (Ph.D.)

  Biology/Biological Sciences

  General

  Louisiana State University

• 2001

  Chineses

  English

  Master's Degree

  Biochemistry and Molecular Biology

  Nanjing University

• Microsoft Excel

  Western Blotting

  Molecular Biology

  Statistics

  PowerPoint

  Fluorescence Microscopy

  Protein Expression

  Cell Biology

  Biochemistry

  Life Sciences

  Genetics

  Molecular Cloning

  Research

  PCR

  Microscopy

  Neurodegeneration

  Microsoft Office

  Cell Culture

  Science

  Data Analysis

  CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome

  Henry L Paulson

  Venkatesha Basrur

  K Matthew Scaglione

  Kai-chun Chen

  Abigail J Renoux

  Michelle Frazer

  Chantal Sellier

  Amy Krans

  Seok Yoon Oh

  Peter K Todd

  Neuron

  The moderately expanded CGG repeats at 5'UTR of FMR1 gene in fragile X tremor ataxia syndrome was found to be translated without ATG initiation

  while dependent on the expanded repeat itself.

  CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome

  Jacqueline M. Stephens

  Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes

  Xiang Gao

  Zuoming Zhang

  Qing Xie

  Haibin Ruan

  Jun Ding

  Jie Bao

  Jing Zhao

  Zixing Wang

  Large-scale screening of disease model through ENU mutagenesis in mice

  Todd PK

  Epigenetics in nucleotide repeat expansion disorders

  L. Aravind

  Lakshminarayan M. Iyer

  Dapeng Zhang

  Frontiers in Genetics

  Discovery of novel DENN proteins: implications for the evolution of eukaryotic intracellular membrane structures and human disease

  Patrick DiMario

  Helya Ghaffari

  Himanshu Raje

  Allison James

  Deletion of Drosophila Nopp140 induces subcellular ribosomopathies

  Jacqueline M Stephens

  Julie A Doucet

  Transcription factor PPAR gamma was found being cleaved by caspases under certain conditions.

  Caspase‐mediated Degradation of PPARγ Proteins in Adipocytes

  Andrew P Lieberman

  Roger L Albin

  Masoud Kamali

  Peter K Todd

  Guy M Lenk

  Julie M Jones

  Adrienne E Grant

  Miriam H Meisler

  Bipolar Disorders

  C9ORF72 expansion in a family with bipolar disorder

  Peter K. Todd

  J. Paul Taylor

  Brian D. Freibaum

  Amy Krans

  function of TDP-43 linked two neurodegenerative diseases: FXTAS and ALS

  TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1

  Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a limited expansion of CGG repeats in the 5' UTR of FMR1. Two mechanisms are proposed to cause FXTAS: RNA gain-of-function

  where CGG RNA sequesters specific proteins

  and translation of CGG repeats into a polyglycine-containing protein

  FMRpolyG. Here we developed transgenic mice expressing CGG repeat RNA with or without FMRpolyG. Expression of FMRpolyG is pathogenic

  while the sole expression of CGG RNA is not. FMRpolyG interacts with the nuclear lamina protein LAP2β and disorganizes the nuclear lamina architecture in neurons differentiated from FXTAS iPS cells. Finally

  expression of LAP2β rescues neuronal death induced by FMRpolyG. Overall

  these results suggest that translation of expanded CGG repeats into FMRpolyG alters nuclear lamina architecture and drives pathogenesis in FXTAS

  Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome

  Patrick J. DiMario

  Mitochondrial defects was identified in Drosophila model of type II hyperprolinemia.

  Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity—establishing a fly model for human type II hyperprolinemia

  He

  University of Michigan Health System

  Texas A&M University-Kingsville

  kingsville

  Texas

  Instructor to teach various level of courses in Biology for undergraduate students and graduate students. Principal Investigator to study molecular mechanisms of neurodegenerative diseases.

  Assistant Professor

  Texas A&M University-Kingsville

  Design and execute biological experiments to find the mechanisms of neurodegenerative diseases

  mentor undergraduate students

  present scientific findings on conferences.

  University of Michigan Health System

  American Society of Cell Biology