Erin Parker

 ErinE. Parker

Erin E. Parker

  • Courses4
  • Reviews4

Biography

Coastal Carolina University - Chemistry



Experience

    Education

    • Winthrop University

      Bachelor's Degree

      Chemistry

    • University of Notre Dame

      Doctor of Philosophy (Ph.D.)

      Organic Chemistry

    • University of Notre Dame

      Laboratory Instructor/Undergraduate Mentor


      Trained and guided an undergraduate student in organic chemistry principles, complex data analysis, and experimental and instrument techniques which resulted to their co-authoring of a scientific publication.

    • University of Notre Dame

      Ph.D. Organic Chemistry


      Discovered and optimized novel methods for chemical synthesis, tested the viability of new reactions using model systems, and communicated those findings in regional and national conferences as well as peer-reviewed publications. Selected project experience: Led efforts in the mechanistic elucidation of propargylic alcohol formation via isolation of a sensitive, key intermediate, which provided a more coherent understanding of the chemical process and allowed for the method’s implementation in more complex systems. Developed a new method for rapidly synthesizing oxindole structures, spearheaded compound characterization, and subsequently built a library of 13 compounds, of which 4 possessed low micromolar activity against brain cancer cell lines.

    • University of Notre Dame


      Assisted in raising over $20,000 for Holy Cross mission work in Uganda. "Strong bodies gight, that weak bodies may be nourished."

    Publications

    • An Amine-Free Approach Toward N-Toluenesulfonyl Amidine Construction: A Phosphite-Mediated Beckmann-Like Coupling of Oximes and p-Toluenesulfonyl Azide

      Angewandte Chemie International Edition

    • An Amine-Free Approach Toward N-Toluenesulfonyl Amidine Construction: A Phosphite-Mediated Beckmann-Like Coupling of Oximes and p-Toluenesulfonyl Azide

      Angewandte Chemie International Edition

    • Stereochemical implications in the synthesis of 3,3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

      Tetrahedron

      3,3′-Spirocyclopropane oxindoles were synthesized in good to excellent yield and diastereoselectivity employing a Kukhtin–Ramirez reaction between readily accessible E-alkylidene oxindoles, commercially available P(NMe2)3, and α-keto esters. The stereoselectivity in the cyclopropanation event can be traced to the starting alkylidene geometry and the propensity of the exocyclic alkene to undergo isomerization in the presence of an electron rich phosphine.

    • An Amine-Free Approach Toward N-Toluenesulfonyl Amidine Construction: A Phosphite-Mediated Beckmann-Like Coupling of Oximes and p-Toluenesulfonyl Azide

      Angewandte Chemie International Edition

    • Stereochemical implications in the synthesis of 3,3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

      Tetrahedron

      3,3′-Spirocyclopropane oxindoles were synthesized in good to excellent yield and diastereoselectivity employing a Kukhtin–Ramirez reaction between readily accessible E-alkylidene oxindoles, commercially available P(NMe2)3, and α-keto esters. The stereoselectivity in the cyclopropanation event can be traced to the starting alkylidene geometry and the propensity of the exocyclic alkene to undergo isomerization in the presence of an electron rich phosphine.

    • Synthesis of Phosphine-Ligated Zinc Acetylide Dimers: Enhanced Reactivity in Carbonyl Additions

      Organometallics

    • An Amine-Free Approach Toward N-Toluenesulfonyl Amidine Construction: A Phosphite-Mediated Beckmann-Like Coupling of Oximes and p-Toluenesulfonyl Azide

      Angewandte Chemie International Edition

    • Stereochemical implications in the synthesis of 3,3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

      Tetrahedron

      3,3′-Spirocyclopropane oxindoles were synthesized in good to excellent yield and diastereoselectivity employing a Kukhtin–Ramirez reaction between readily accessible E-alkylidene oxindoles, commercially available P(NMe2)3, and α-keto esters. The stereoselectivity in the cyclopropanation event can be traced to the starting alkylidene geometry and the propensity of the exocyclic alkene to undergo isomerization in the presence of an electron rich phosphine.

    • Synthesis of Phosphine-Ligated Zinc Acetylide Dimers: Enhanced Reactivity in Carbonyl Additions

      Organometallics

    • Direct Acyl Substitution of Carboxylic Acids: A Chemoselective O- to N- Acyl Migration in the Traceless Staudinger Ligation.

      Chemistry - A European Journal

    • An Amine-Free Approach Toward N-Toluenesulfonyl Amidine Construction: A Phosphite-Mediated Beckmann-Like Coupling of Oximes and p-Toluenesulfonyl Azide

      Angewandte Chemie International Edition

    • Stereochemical implications in the synthesis of 3,3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

      Tetrahedron

      3,3′-Spirocyclopropane oxindoles were synthesized in good to excellent yield and diastereoselectivity employing a Kukhtin–Ramirez reaction between readily accessible E-alkylidene oxindoles, commercially available P(NMe2)3, and α-keto esters. The stereoselectivity in the cyclopropanation event can be traced to the starting alkylidene geometry and the propensity of the exocyclic alkene to undergo isomerization in the presence of an electron rich phosphine.

    • Synthesis of Phosphine-Ligated Zinc Acetylide Dimers: Enhanced Reactivity in Carbonyl Additions

      Organometallics

    • Direct Acyl Substitution of Carboxylic Acids: A Chemoselective O- to N- Acyl Migration in the Traceless Staudinger Ligation.

      Chemistry - A European Journal

    • Phosphine-Based Redox Catalysis in the Direct Traceless Staudinger Ligation of Carboxylic Acids

      Angewandte Chemie International Edition

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