David Kling

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DavidE. Kling

David E. Kling

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Biography

Worcester State University - Biology

Research Scientist/Technical Writer/Educator
David E.
Kling
Greater Boston Area
Biologist excelling in novel approaches to problem-solving, assay development, and generating precision data sets. Communicates clearly to both scientific and lay audiences. Recipient of NIH and intramural funding (Massachusetts General Hospital). Specific areas of expertise include assay/model development in vitro, ex vivo, and in vivo, histopathology, immunohistochemistry, digital image analysis, and bioinformatics (DNAseq/RNAseq). Possesses deep knowledge of a broad range of biological processes including:
• Disease models - idiopathic pulmonary fibrosis, COPD, cystic fibrosis, tissue adhesions
• Toxicology - mechanisms of cell-specific genotoxicity and cytotoxicity
• Infectious diseases - host-pathogen interactions/mucosal immunity
• Gene expression - nuclear hormone receptor transcriptional networks
• Signal-transduction - ERK, JNK, p38 MAP kinase pathways
• Metabolism - eukaryotic and prokaryotic
• Microbiome - putative roles in cancer and inflammatory diseases

Experience

    Education

    • University of Massachusetts, Amherst

      Ph.D.

      Molecular and Cellular Biology
      • Carried out molecular characterization of the alpha C-protein (ACP) N-terminal region from group B Streptococcus (GBS) • Characterized unique immunological properties of the N-terminal portion of the ACP; demonstration that antibodies raised to this peptide are protective both in vitro and in vivo against GBS infections • Characterized the proteolytic mechanisms of alpha C-protein (ACP) antigen peptide heterogeneity from GBS

    Publications

    • Please see my publications @ Google Scholar and @ ResearchGate

      https://scholar.google.com/citations?user=5cMQJAoAAAAJ&hl=en

      Selected publications available for download at https://www.researchgate.net/profile/David_Kling

    BI 141

    2.8(6)

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