Daniel Williams

 DanielB. Williams

Daniel B. Williams

  • Courses3
  • Reviews5

Biography

Winston Salem State University - Biology


Resume

  • 2015

    Home Schooling

    Guilford Technical Community College

    Evidence Based STEM teaching

    Design and Interpretation of Clinical Trials

    Johns Hopkins University via Coursera

    XWPPJGXVHZFA

    What is Data Science?

    URWQXW9BYQW5

    Coursera (IBM)

    Archive Vision and Change Scholar

    American Physiological Society

    AXFF6PYU6B

    Epigenetic Control of Gene Expression

    University of Melbourne (via Coursera)

    Online Teaching Essentials

    The City University of New York

  • 1994

    Columbia University

    Brooklyn College

    Winston-Salem State University

    New Mexico Highlands University

    New York City Metropolitan Area

    Lecturer (Doctoral Schedule) and Coordinator of Core Biology

    Brooklyn College

    WSSU is an HBCU mainly emphasizing teaching but moving more in a research direction. I am working on the forefront of both the teaching and research priorities. On the teaching

    I am curious in why the traditional techniques I learned by are not as effective as before

    and am one of the leaders in trying new approaches and technologies to student learning

    especially to non-biology majors. I am also

    with some of my colleagues

    designing new topical non-major courses

    such as environmental biology

    human biology and disease

    and human reproduction and development. I personally designed or co-designed two of those courses. I have also reviewed and edited a number of non-major textbooks and lab books. For research my main interest is in hormonal modulation of neurotransmitter systems. My main hormones of interest are insulin

    cortisols

    and progesterones. My research may have implications in diabetes

    food intake

    inflammation and autoimmunity

    PMDD

    anxiety

    stress

    and effects of environmental exposure to hormone mimetics. I am also screening potential drugs designed for other neurotransmitter systems for cross-effects at GABA-A receptors.

    Winston-Salem State University

    Adjunct Professor

    I taught Anatomy and Physiology I lecture and lab

    including the cat dissections

    Guilford Technical Community College

    New Mexico Highlands University

    Las Vegas

    NM

    Recruited via an NIH grant. I started the steroid work I have recently expanded and published.\nTaught biomolecules

    endocrinology

    graduate and undergraduate cell biology

    graduate genes and disease seminar; and a mixed graduate/undergraduate new course in neurobiology.

    Assistant Professor of Cell Biology

    I worked on my research project on the effects of different drugs on the shape of the GABA-A receptor.

    Columbia University

    Mount Ida College

    Newton

    MA

    In charge of Natural and Applied Sciences

    biology

    chemistry

    forensic science

    and environmental sustainability

    including all faculty

    annual reports

    assessment

    budgets

    and hiring.

    Associate Professor and Chair of Natural and Applied Sciences

    PhD

    The Integrated Program. Gave experience in microbiology

    genetics

    cancer

    and development as well as the neuroscience/hormone related work I currently do.

    Cellular

    Molecular and Biophysical Studies

    Cellular Membranes and Organelles

    Cell and Tissue Culture

    Eukaryotic Molecular Biology

    Immunology and Serology

    Biology of Cancer

    Advanced Biochemistry

    Calculus for Business

    Economics and Biology

    Cell Ultrastructure and Function

    General Physiology

    Intro to Pharmacology

    Classroom Management

    Genetics

    Advanced Cell and Developmental Biology

    General Ecology

    Cytogenetics

    Chemistry II

    Calculus II

    Education Practicum

    Immunology

    Coursera (University of Toronto)

    Bioinfomatic Methods I

    XWKMYL6EPQ3S

  • 1992

    Rutgers University

    National Institutes of Health

    Guilford Technical Community College

    I taught Labs for General Biology

    Molecular Biology

    and Genetics.

    Rutgers University

    Marymount Manhattan College

    Greater New York City Area

    Teaching Anatomy

    Evolution

    and Drugs and Brain.

    Visiting Associate Professor of Biology

    Special pharmacology research fellow in NINDS/NIGMS working on dopamine receptor pharmacology

    desensitization

    and signaling.

    National Institutes of Health

    Society for Neuroscience

    American Association for the Advancement of Science

    Attending various meetings and workshops for major and course curriculum redesign based current research and in Vision and Change.

    AAC&U and PKAL

    Member

    American Society for Pharmacology and Experimental Therapeutics

    English

    Global Medical Discovery Article of Interest:

    For Williams DB (2011) A mutant residue in the third transmembrane region of the GABA-A alpha1 subunit causes increased agonistic neurosteroid responses. Neurochem Int. 58: 794-803. (doi:10.1016/j.neuint.2011.03.005)

    Tri Beta

    Induction as honorary member

    Research Highlighted in Target Intelligence Service

    For Williams DB (2011) A mutant residue in the third transmembrane region of the GABA-A alpha1 subunit causes increased agonistic neurosteroid responses. Neurochem Int. 58: 794-803. (doi:10.1016/j.neuint.2011.03.005)

    Faculty of 1000

    MS

    Teaching assistant for genetics

    general biology

    molecular biology

    \nMasters' research on hormone effects on GABA-A receptor ligand binding.\n

    Biology

    Coral Lansbury Award for Best Graduate Student

  • 1989

    BA

    Biology

    Rahman Award as top biology student.\nAthenaeum Honor Society

  • 1985

    I was co-valedictorian.

    Highland Regional High School

  • JDRF

    Parent Mentor and other activities

    Cell Biology

    Scientific Writing

    Research

    Curriculum Design and Assessment

    Educational Assessment

    Classroom

    Pharmacology

    Instructional Design

    Genetics

    Teaching

    Cell Signaling

    Cell Culture

    Curriculum Development

    College Teaching

    Proposal Writing

    Teaching Writing

    Molecular Biology

    Electrophysiology

    Animal Welfare

    University Teaching

    Inhibitory effects if insulin on GABA-A currents modulated by the GABA-A alpha subunit

    Insulin

    when co-applied with GABA

    can cause an inhibition of the induced current at GABAA receptors. Main methods: This study investigated that inhibitory effect of insulin at a variety of receptor isoforms

    concentrating on α1

    α2

    and α4 containing receptors. Various isoforms were expressed in Xenopus oocytes and currents determined using two-electrode voltage clamp. Key findings: Submaximal GABA currents at all isoforms studied were inhibited by nanomolar concentrations of insulin. At α2 and α4 containing forms

    insulin could inhibit maximal GABA currents. The ability to inhibit maximal currents

    and the general potency and effects at submaximal currents paralleled the number of potential MAPK sites on the α subunits. Significance: The differences in insulin inhibition of GABA currents at different α containing GABAA receptors could be important in autocrine and paracrine control of hormone secretion in the pancreas

    and in control of reward and food intake circuits of the brain.

    Inhibitory effects if insulin on GABA-A currents modulated by the GABA-A alpha subunit

    Pregnane derived steroids have agonistic and antagonistic actions at GABAA receptors. Putative binding sites for agonistic neurosteroids are located within the transmembrane (TM) regions. A mutation within the rat α1 TM3 region

    S299C

    caused the expressed receptors to have unusual and extreme sensitivity to agonistic neurosteroids. For mutant α1S299C receptors

    with wild type β and γ subunits

    expressed in Xenopus oocytes

    steroids activated the GABAA receptors in the absence of GABA. Maximal steroid induced currents were about half of maximal GABA currents. The steroid activation was biphasic with EC50’s much lower than wild type

    in subnanomolar and nanomolar concentrations

    while the wild type had only one activation peak with near micromolar EC50. These currents could be blocked by both picrotoxin and an antagonist neurosteroid. The steroids did not seem to potentiate significantly submaximal GABA currents. The α1S299C mutation did not affect responses to the extracellularly acting partial agonist piperidine-4-sulfate. Substituted cysteine experiments indicate that this mutant can be modified by pCMBS- when the sulfhydryl reagent is added with the higher steroid concentration for activation but not the lower steroid concentration. The pCMBS- will also immediately block the high concentration steroid current. Taken together the data suggest that α1S299 is at least important in the in transduction of the steroid binding to the rest of the receptor.

    A mutant residue in the third transmembrane region of the GABA-A alpha1 subunit causes increased agonistic neurosteroid responses.

    In the CNS

    GABA and insulin seem to contribute to similar processes

    including neuronal survival; learning and reward; and energy balance and food intake. It is likely then that insulin and GABA may interact

    perhaps at the GABAA receptor. One such interaction has already been described [33]; in it a micromolar concentration of insulin causes the insertion of GABAA receptors into the cell membrane

    increasing GABA current. I have discovered another effect of insulin on GABAA currents. Using a receptor isoform α1β2γ2s that is the likely main neuronal GABAA isoform expressed recombinantly in Xenopus oocytes

    insulin inhibits GABA induced current when applied simultaneously with low concentrations of GABA. Insulin will significantly inhibit currents induced by EC30-50 concentrations of GABA by about 40%. Insulin is potent in this effect; IC50’s of insulin in a two site model were found to be about 4.5 x10-10 M. The insulin effect on the GABA dose responses looked like that of a competitive antagonist. However

    an effect of phosphorylation on the GABAA from the insulin receptor signal transduction pathway cannot yet be dismissed.

    A novel

    rapid inhibitory effect of insulin on α1β2γ2S γ-aminobutyric acid type A receptors.

    \n\n\n\n

    Letter to the Editor of Nexus Magazine

    Continuing to gather preliminary data on histamine-GABA-A receptor ligand interactions.\n

    Society for Neuroscience poster 2014

    Williams

    Daniel

    Marymount Manhattan College

    Mount Ida College

Possible Matching Profiles

The following profiles may or may not be the same professor:

Possible Matching Profiles

The following profiles may or may not be the same professor:

  • Daniel Williams (00% Match)
    Adjunct Instructor
    Los Angeles Community College District - Los Angeles Community College District

  • Daniel Williams (00% Match)
    Staff Associate
    Salem State University - Salem State University (ssa)

  • Daniel Williams (00% Match)
    Adjunct Associate Professor
    Baruch College - Baruch College Adj

  • Daniel Williams (00% Match)
    Professor
    Baruch College - Baruch College

  • Daniel Williams (00% Match)
    Assistant Professor
    Coastal Carolina University - Coastal Carolina University

  • Daniel Williams (00% Match)
    Instructor
    University Of South Carolina - University Of South Carolina

BIO 3366

3.3(3)

GENETICS

2.5(1)