Experience

• The Pennsylvania State University

  Graduate Student

  Dissertation research focused on binding kinetics of prolactins from different species and effects on differentiation and lactogenesis in the mammary gland.

• Purdue University

  Graduate Student, MS

  Research developed chromatographic methods to measure the secretion and absorption of bile acids in cattle as a mechanism for the diarrhea caused by high magnesium in feeds.

• Baylor College of Medicine

  Research Associate

  D. Joseph worked at Baylor College of Medicine as a Research Associate

• Pioneer Valley Life Sciences Institute

  Co-Director, Rays of Hope Center for Breast Cancer Research

  D. Joseph worked at Pioneer Valley Life Sciences Institute as a Co-Director, Rays of Hope Center for Breast Cancer Research

• Pioneer Valley Life Sciences Institute

  Director, Breast Cancer Working Group

  D. Joseph worked at Pioneer Valley Life Sciences Institute as a Director, Breast Cancer Working Group

• Pioneer Valley Life Sciences Institute

  Scientific Director

  Development of diagnostic tests predicting the behavior of early breast lesions and informing therapies are major priorities. These include gene expression signatures and metabolic profiles associated with risk and resistance to breast cancer. The Institute maintains a registry of breast cancer patients and control groups through the Rays of Hope Center for Breast Cancer Research. The cohort has provided extensive interview data and broad consent for use of tissues. We maintain a panel of primary cells suitable for gene editing approaches and paired samples of affected and unaffected breasts from women undergoing double mastectomy. Approaches to mitigate the complications of diabetes through treatments that enhance beta cell function and restore insulin sensitivity is also a theme that overlaps with investigations of the links between obesity and cancer risk.

• University of Massachusetts Amherst

  Professor

  Teaching in genetics and molecular medicine.
  Research focus is mechanisms of risk and resistance to breast cancer.