Resume

• 2000

  Ph.D.

  Nuclear Structure and Function

  University of Toronto

• 1998

  M.Sc.

  Anatomy and Cell Biology

  University of Saskatchewan

• Lecturing

  Cell Biology

  Microscopy

  University Teaching

  Science

  Higher Education

  Genetics

  Biochemistry

  Molecular Biology

  Transcription factories and nuclear organization of the genome.

  The dynamic compartmental organization of the transcriptional machinery in mammalian nuclei places particular constraints on the spatial organization of the genome. The clustering of active RNA polymerase I transcription units from several chromosomes at nucleoli is probably the best-characterized and universally accepted example. RNA polymerase II localization in mammalian nuclei occurs in distinct concentrated foci that are several-fold fewer in number compared to the number of active genes and transcription units. Individual transcribed genes cluster at these shared transcription factories in a nonrandom manner

  preferentially associating with heterologous

  coregulated genes. We suggest that the three-dimensional (3D) conformation and relative arrangement of chromosomes in the nucleus has a major role in delivering tissue-specific gene-expression programs.

  Transcription factories and nuclear organization of the genome.

  Christopher

  Eskiw

  Brunel University

  University of Saskatchewan

  Babraham Institute

  University of Oxford

  Genome Organization and Function

  Brunel University

  Post Doctoral Fellow

  Babraham Institute

  Post Doctoral Fellow

  University of Oxford

  University of Saskatchewan

  Nutrigenomics

  Assistant Professor

  Saskatchewan

  Canada